Modeling Rett Syndrome with Stem Cells
نویسندگان
چکیده
The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et al. (2010) now use iPSC technology to generate, characterize, and treat an in vitro model for the autism spectrum disorder Rett syndrome.
منابع مشابه
A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we developed a culture system using induced pluripotent stem cells (iPSCs) from RTT patients' fibroblasts. RTT patients' iPSCs are able to undergo X-inactivation and generate functional ne...
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ورودعنوان ژورنال:
- Cell
دوره 143 شماره
صفحات -
تاریخ انتشار 2010